Commercial & Investment Real Estate Specialists
2275 Highway F #LOT 1
Defiance, MO, 63341
$3,450,000
5 Beds
4 Baths
2,815 SqFt
22 Acres
Add
MLS #MIS26053202 image #0
Imagine owning a timeless piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and nephew/adopted son Jonathan Bryan helped shape this remarkable landscape. A captivating driveway leads around to a ONE-OF-A-KIND property built in the 1840’s for Jonathan Bryan. “Bryan Mill” rests gracefully on 22+/- acres providing a peaceful & tranquil atmosphere, conveniently located near Augusta & Defiance, with a STRIKING, FINELY DETAILED, FULLY FURNISHED, FRENCH INSPIRED w/exquisite imported antiques curated by Annie Brahler of EuroTrash, Inc. At the heart of the property is an 1840s built cottage exquisitely reimagined as a luxurious country residence, and STATELY early 1800’s built 68’x36’ Stone mill/outbuilding with 2 BEAUTIFUL automatic solid wood doors, floor-to-ceiling Stone fireplace, 37’+/- vaulted ceiling, kitchen, 2 half baths, & an abundant amount of storage space, AND a COMPLETELY REDONE stone chicken coop. Throughout the cottage, historic details have been carefully preserved and complemented by modern mechanical systems, conveniences, and automated security and surveillance. The home boasts 2,815+/- SqFt, 5 bedrooms, 2 full baths, with mostly original hardwood flooring throughout and a kitchen anchored by a 65 inch La Cornue Chateau Series range. The historic mill is equally remarkable. Beautifully restored and fully climate-controlled with modern HVAC systems, the mill features a catering kitchen and expansive event and entertaining spaces. It offers an extraordinary setting for private dinners, celebrations, retreats, creative pursuits, or large-scale entertaining—all without ever leaving the privacy of the estate. Create a legacy where your children and grandchildren can reconnect with nature—plant gardens, raise animals, ride horses, explore miles of side-by-side trails, or simply enjoy the peace and beauty that only a property like this can offer. Beyond the residence, private acreage unfold through rolling fields, mature woods, gardens, and majestic private pathways winding throughout the estate. A dramatic boulder firepit creates an intimate destination for evenings outdoors, while even the custom chicken coop has been thoughtfully designed to complement the architecture and character of the property. Opportunities to own a tract with this combination of history, natural beauty, privacy, and location are exceptionally rare, especially with frontage on the coveted Hwy F. This isn’t just land—it’s a place where your family’s next chapter can begin and memories can be made for generations to come. MUST SEE! *ALL PARTIES UNDERSTAND PROPERTY IS SUBJECT TO SURVEY AND APPROVED THROUGH CITY & ALL GOVERNMENTAL AUTHORITIES.* Additional acreage FOR SALE. See MLS #’s: 26053203 (LOT #2, 12.5+/- ACRES), 26053360 (LOT #3, 38.5+/- ACRES), & 26053204 (LOT #4, 32+/- ACRES).

Property Details

Price:
$3,450,000
MLS #:
MIS26053202
Status:
Active
Beds:
5
Baths:
4
Type:
Single Family
Subtype:
Single Family Residence
Neighborhood:
412francishowellcntrl
Listed Date:
Sep 6, 2026
Finished Sq Ft:
2,815
Lot Size:
958,320 sqft / 22.00 acres (approx)
Year Built:
1843
412 – Francis Howell Cntrl412francishowellcntrlFrancis Howell R-iiiDaniel Boone Elem.Francis Howell MiddleFrancis Howell Central High

Ask a Question

See this Listing

Send
  

Schools

School District:
Francis Howell R-III
Elementary School:
Daniel Boone Elem.
Middle School:
Francis Howell Middle
High School:
Francis Howell Central High

Interior

Above Grade Finished Area
2815
Appliances
Dishwasher, Disposal, Built-In Freezer, Range Hood, Gas Range, Built-In Refrigerator, Washer/Dryer, Tankless Water Heater, Water Purifier
Bathrooms
2 Full Bathrooms, 2 Half Bathrooms
Cooling
Central Air, Electric
Fireplaces Total
3
Heating
Forced Air
Interior Features
Beamed Ceilings, Built-in Features, Center Hall Floorplan, Chandelier, Eat-in Kitchen, Entrance Foyer, Natural Woodwork, Recessed Lighting, Smart Thermostat, Sound System, Vaulted Ceiling(s)
Laundry Features
In Basement
Levels
Three Or More
Main Level Bedrooms
1

Exterior

Architectural Style
Colonial, French Provincial, Historic, Traditional
Construction Materials
Stone
Exterior Features
Fire Pit, Private Entrance
Lot Features
Cleared, Many Trees, Meadow, Pasture, Scattered Woods
Patio And Porch Features
Front Porch, Patio, Rear Porch
Roof
Wood
Security Features
Security System, Security System Owned
Window Features
Window Coverings

Financial

Map

Community

Market Summary

Current real estate data for Single Family in Defiance as of Sep 15, 2026
21
Single Family Listed
55
Avg DOM
391
Avg $ / SqFt
$1,224,012
Avg List Price

Property Summary

    Located in the N/A subdivision, 2275 Highway F #LOT 1 Defiance MO is a Single Family for sale in Defiance, MO, 63341. It is listed for $3,450,000 and features 5 beds, 4 baths, and has approximately 2,815 square feet of living space, and was originally constructed in 1843. The current price per square foot is $1,226. The average price per square foot for Single Family listings in Defiance is $391. The average listing price for Single Family in Defiance is $1,224,012. To schedule a showing of MLS#mis26053202 at 2275 Highway F #LOT 1 in Defiance, MO, contact your Realty Exchange agent at (314) 647-2220.

Similar Listings Nearby

2275 Highway F #LOT 1
Defiance, MO

Reset password

Enter your email address and we will send you a link to change your password.

Get started with your account

to save your favorite properties and more

Sign up with email

Get started with your account

to save your favorite properties and more

By clicking the «SIGN UP» button you agree to the Terms of Use and Privacy Policy